PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]-
Erianin
CAS: 95041-90-0
Molecular Formula: C18H22O5
PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]- - Names and Identifiers
| Name | Erianin |
| Synonyms | Erianin Erianin 95041-90-0 3'-Hydroxy-3,4,4',5-tetraMethoxybibenzyl 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol 2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]benzolol PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]- |
| CAS | 95041-90-0 |
| EINECS | 1312995-182-4 |
| InChI | InChI=1/C18H22O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h7-11,19H,5-6H2,1-4H3 |
PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]- - Physico-chemical Properties
| Molecular Formula | C18H22O5 |
| Molar Mass | 318.36 |
| Density | 1.147 |
| Boling Point | 439.1±40.0 °C(Predicted) |
| Flash Point | 219.4°C |
| Solubility | Soluble in fat-soluble solvents such as chloroform, hardly soluble in water |
| Vapor Presure | 2.54E-08mmHg at 25°C |
| Appearance | White powder or crystal |
| pKa | 9.99±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.553 |
| MDL | MFCD06795132 |
| Physical and Chemical Properties | Soluble in fat-soluble solvents such as chloroform, insoluble in water from Dendrobium drumstick |
| In vitro study | Erianin is often used as antipyretic and analgesic agent. Erianin belongs to bibenzyl derivatives in structure, with the activity of anti-virus, anti-bacterial, as well as anti-benign prostatic hyperplasia. Erianin has obvious damage on 2LL-IDO cells, Erianin basically has no cytotoxicity on human normal liver cell line L02, and cell viability is maintained at around 85%. Erianin inhibits the growth of HeLa cells and induces apoptosis in a dose‑ and time‑dependent manner, inducing cell cycle arrest at the G2/M stage. Erianin treatment also increases the expression of Bax and caspase‑3, but decreases levels of Bcl‑2 and phosphorylated‑ERK1/2. |
PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]- - Risk and Safety
| HS Code | 29089990 |
PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]- - Reference
| Reference Show more | 1. Lin Tao, Geng Huichun, Li maoxan, etc. Preparation of standard sample for purity of mulanolin [J]. Quality and safety of agricultural products, 2018(6). 2. Zhao Qun, fan Linglin, Liu Yingxiang, Bi Yun, Guo Jian, Pan Longrui, Tan Yan, Yu Xianjun. Experimental study on apoptosis of breast cancer cells induced by activation of JNK pathway [J]. Journal of Hubei University of Medicine, 2020,39(05):419-426 431. 3. Du, Bo, et al. Chemico-biological interactions 324 (2020): 109089.https://doi.org/10.1016/j.cbi.2020.109089 4. Zhenhui Wan, Qingjun Huang,Study on chemical constituents of different species of Dendrobium,E3S Web Conf. 165 05026 (2020). DOI: 10.1051/e3sconf/202016505026 5. Yu, Zengyang, et al. "Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway." Scientific reports 6.1 (2016): 1-15.https://doi.org/10.1038/srep34306 6. Yu, Zengyang, et al. "Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway." Scientific reports 6.1 (2016): 1-15.https://doi.org/10.1038/srep34306 7. [IF=3.998] Yu Zengyang et al."Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway."Sci Rep-Uk. 2016 Sep;6(1):1-15 8. [IF=3.266] Jing Sun et al."Erianin inhibits the proliferation of T47D cells by inhibiting cell cycles inducing apoptosis and suppressing migration."Am J Transl Res. 2016; 8(7): 3077-3086 9. [IF=13.493] Chen Peng et al."Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis."Signal Transduct Tar. 2020 May;5(1):1-11 10. [IF=10.435] Mo Canlong et al."Development of erianin-loaded dendritic mesoporous silica nanospheres with pro-apoptotic effects and enhanced topical delivery."J Nanobiotechnol. 2020 Dec;18(1):1-14 11. [IF=6.023] Hualing Xie et al."Synergistic cytotoxicity of erianin, a bisbenzyl in the dietetic Chinese herb Dendrobium against breast cancer cells."Food Chem Toxicol. 2021 Mar;149:111960 12. [IF=5.81] Yu Xiang et al."Natural Product Erianin Inhibits Bladder Cancer Cell Growth by Inducing Ferroptosis via NRF2 Inactivation."Front Pharmacol. 2021; 12: 775506 13. [IF=4.162] Yihan Sun et al."Dual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer."Drug Des Dev Ther. 2020; 14: 3301-3313 14. [IF=3.723] Bo Dou et al."Anti-inflammation of Erianin in dextran sulphate sodium-induced ulcerative colitis mice model via collaborative regulation of TLR4 and STAT3."Chem-Biol Interact. 2020 Jun;324:109089 15. [IF=2.926] Zhang Peng et al."Exploration of the Tolerance Ability of a Cell-Free Biosynthesis System to Toxic Substances."Appl Biochem Biotech. 2019 Dec;189(4):1096-1107 16. [IF=4.799] Xueke Li et al."Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction."Invest Ophth Vis Sci. 2022 Jan;63(1):27-27 17. [IF=2.01] Pang Xuecheng et al."Erianin Suppresses Endometrial Cancer Progression by Regulating the miR-661/BOK Axis."Rev Bras Farmacogn. 2021 Dec;:1-9 |
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Tel: 0714-3999186
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